Cholesterol Biosynthesis
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 10 genes have a known function matching the annotation |
Why this annotation
The top hub genes MSMO1 (methylsterol monooxygenase), SQLE (squalene epoxidase), and STARD4 (steroidogenic acute regulatory domain protein) are all enzymes in the cholesterol/sterol biosynthesis pathway. LDLR (LDL receptor) mediates cholesterol uptake. Together these define a cholesterol metabolism program. NDFIP2 and CSF1 are peripheral members. This module is consistent with lipid metabolic reprogramming in gd T cells.
Genes
CRIM1, CSF1, HS3ST3B1, LDLR, MSMO1, MUC12, NDFIP2, REG1A, SQLE, STARD4
Most correlated modules
- Heat Shock Response · correlation 0.83
- AHR/NF-κB Survival · correlation 0.78
- Gut-homing Residence · correlation 0.76
- Immature T Cell · correlation 0.66
- IRF4 T-cell Activation · correlation 0.66
- ER/Osmotic Stress · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.