AHR/NF-κB Survival
Gene co-expression module in Gamma-delta T cells
| Category | Immune regulation |
|---|---|
| Genes | 33 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 33 genes have a known function matching the annotation |
Why this annotation
Hub genes AHR (aryl hydrocarbon receptor), BIRC3, TANK, PELI1, and DUSP4 collectively define an NF-κB/AHR stress-survival signaling program. AHR integrates xenobiotic and inflammatory signals; BIRC3 and TANK are direct NF-κB pathway components; PELI1 is an E3 ligase in TLR/NF-κB signaling; DUSP4 provides feedback MAPK regulation. BCL2L11 (BIM) and TP53INP1 add apoptotic regulation downstream of stress. AREG (amphiregulin) and NECTIN3 suggest tissue-repair outputs. This is coherent as an AHR-driven NF-κB activation and survival module.
Genes
ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3, CBL, CDR2, CHD7, CHKA, DEGS1, DUSP4, DYNLT3, FAS, GPBP1, HES4, NECTIN3, NUDT4, P4HA1, PELI1, PGK1, PPP1R2, PRDX6, RAB11FIP1, RAPGEF6, SAMD8, SCUBE1, SLC19A2, TANK, TP53INP1, WWTR1
Most correlated modules
- Hypoxia Tissue Adaptation · correlation 0.94
- Activation Stress Response · correlation 0.89
- ER Stress Response · correlation 0.86
- T Cell Exhaustion · correlation 0.84
- mRNA Splicing Regulation · correlation 0.83
- Gut-homing Residence · correlation 0.83
- NK Receptor Expression · correlation 0.83
- IRF4 T-cell Activation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.