Gut-homing Residence
Gene co-expression module in Gamma-delta T cells
| Category | Tissue residence |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes CCR9 (gut-homing receptor), CD101 (intestinal T cell marker), CD9 (tissue-resident tetraspanin), ADAM28 (lymphocyte metalloprotease), and ASB2 (T cell differentiation E3 ligase) collectively define a gut-homing, intestinal tissue-resident gd T cell subset. LZTFL1 (ciliary/trafficking) and RAB3GAP1 (vesicle trafficking) support specialized cellular organization. Low pct positive (6.3%) fits a rare tissue-resident subset.
Genes
ADAM28, ASB2, ATP8B4, CAPG, CCR9, CD101, CD9, DAPK2, DENND1B, ISYNA1, LZTFL1, MSH3, NBL1, PELO, RAB3GAP1, SLC12A6, TRPM2
Most correlated modules
- Tissue Resident CD103+ · correlation 0.92
- NK Receptor Expression · correlation 0.91
- Hypoxia Tissue Adaptation · correlation 0.88
- Activation Stress Response · correlation 0.88
- AHR/NF-κB Survival · correlation 0.83
- Immature T Cell · correlation 0.81
- Chromatin Repression · correlation 0.80
- DNA Repair Housekeeping · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.