ER/Osmotic Stress
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
This module neighbors M118 (heat shock) and shares chaperone genes HSPB1 (HSP27), DNAJA4, HSPA4, FKBP4 (Hsp90 co-chaperone), and ST13 (Hsc70 co-chaperone). SERPINH1 (HSP47) is an ER-resident collagen chaperone. SLC5A3 (myo-inositol transporter) is a known osmotic stress response gene. SOD1 addresses oxidative stress. NUDC (nuclear distribution protein) and SNAP23 (SNARE protein) are more peripheral. The combination of ER chaperones, osmotic stress response, and small HSPs distinguishes this from M118's canonical cytoplasmic heat shock program, suggesting an ER/osmotic stress variant.
Genes
ABHD3, DNAJA4, FKBP4, HIBCH, HSD17B7, HSPA4, HSPB1, MBNL2, MRPL18, NUDC, PWWP3A, SERPINH1, SLC5A3, SNAP23, SOD1, ST13
Most correlated modules
- Heat Shock Response · correlation 0.78
- Proteostasis/Chaperonin · correlation 0.75
- IRF4 T-cell Activation · correlation 0.65
- Cholesterol Biosynthesis · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.