Heat Shock Response
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 22 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 18 of 22 genes have a known function matching the annotation |
Why this annotation
The module is dominated almost entirely by canonical heat shock proteins and co-chaperones: HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA6, HSPH1, HSPE1, HSPD1, DNAJB1, DNAJB4, DNAJA1, BAG3, AHSA1, STIP1, CCT4, TCP1, CHORDC1, CACYBP. This is a tightly coherent ('core') proteotoxic/heat shock stress response module. Neighbor M67 shares chaperone genes (HSPB1, DNAJA4, HSPA4), confirming this neighborhood represents a heat shock stress program.
Genes
AHSA1, BAG3, CACYBP, CCT4, CHORDC1, DNAJA1, DNAJB1, DNAJB4, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA6, HSPD1, HSPE1, HSPH1, NKRF, PTGES3, STIP1, TCP1, TSPYL4, UBC
Most correlated modules
- Cholesterol Biosynthesis · correlation 0.83
- AHR/NF-κB Survival · correlation 0.79
- ER/Osmotic Stress · correlation 0.78
- Gut-homing Residence · correlation 0.67
- Immature T Cell · correlation 0.64
- IRF4 T-cell Activation · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.