ER Protein Biogenesis
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 19 genes have a known function matching the annotation |
Why this annotation
Weak coherence module with diffuse gene membership. EMC10 (ER membrane complex subunit), AUP1 (ER-associated lipid droplet protein), DNAJC1 (ER-localised DnaJ chaperone) point toward ER function. GLUD1 is mitochondrial glutamate metabolism. MARK2 and KLC1 involve vesicular/cytoskeletal transport. No tight single program; most consistent interpretation is a housekeeping/ER protein biogenesis cluster given ER-associated hubs. Weak coherence limits confidence.
Genes
AUP1, BAZ1B, DNAJC1, EMC10, EML3, FAM32A, FRG1, GLUD1, KLC1, MAF1, MARK2, METAP2, MMADHC, PPP6R2, RAVER1, TNIP2, USP39, ZMAT2, ZMIZ1
Most correlated modules
- RNA Splicing Processing · correlation 0.87
- RNA Binding/Splicing · correlation 0.85
- Transcriptional Repressor Complex · correlation 0.84
- RNA Surveillance/NMD · correlation 0.80
- Chromatin Architecture · correlation 0.78
- T Cell Phosphatase Signaling · correlation 0.77
- mRNA Splicing · correlation 0.76
- RNA Processing · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.