CITED4 — Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
CITED4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CITED4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Hypoxia metabolic stress Stress | ARG2, ARL4D, AXIN2, BNIP3, CNKSR2, GCA, GSTM3, ID3 +13 more | View in SCUBA |
| Endothelial | Procoagulant TGF-β Response Inflammation | CSF3, EHD1, F3, LAMC1, LIPG, MED24, PLEKHO1, PMEPA1 +7 more | View in SCUBA |
| Gamma-delta T cells | Redox Stress Response Stress | BEX2, BEX4, EEF1A1, FMNL3, FTL, GRINA, LTBP3, MICAL1 +5 more | |
| Innate lymphoid cells | AP-1 Transcriptional Activation DNA regulation & transcription | AHNAK, ALYREF, CD81, CDV3, ESYT2, ETS1, GNAI2, GRK2 +28 more | View in SCUBA |
| Monocytes | Pentose Phosphate Pathway Innate immunity | ACAP1, AP5B1, CCDC69, CCND3, CORO2A, DYSF, EIF4E3, FLOT2 +4 more | View in SCUBA |
About the gene
| Chromosome | 1: 40861054-40862363 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Transcription, Transcription regulation |
Function
Acts as a transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.