BEX2 — Brain expressed X-linked 2
BEX2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BEX2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | AIF1, AK5, APBA2, BEND5, C1orf162, CBR3, CYSLTR1, ENC1 +21 more | View in SCUBA |
| Gamma-delta T cells | Redox Stress Response Stress | BEX4, CITED4, EEF1A1, FMNL3, FTL, GRINA, LTBP3, MICAL1 +5 more | |
| Natural Killer cells | Glucocorticoid Response Immune regulation | AREG, ARF6, BCLAF1, BEX4, ELF1, ELL2, EPC1, GABARAPL1 +11 more | View in SCUBA |
About the gene
| Synonyms | DJ79P11.1 |
|---|---|
| Chromosome | X: 103309346-103311007 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis, Cell cycle |
Function
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.