FTL — Ferritin light chain

FTL belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

FTL's module in each cell type

Cell type	Module	Shares the module with
Endothelial	Hypoxia Stress Response Stress	ABCA5, ALDH2, BAALC, CIRBP, EGLN3, EPB41, FARP1, LRP5 +7 more	View in SCUBA
Enterocytes	Lysosomal/ferritin housekeeping Housekeeping	APLP2, CD164, CRIP1, CST3, EDF1, FTH1, GPA33, ITM2B +5 more	View in SCUBA
Fibroblasts	Complement-secreting Fibroblast Immune interaction	ADI1, ARL6IP5, C1R, C2, CYB5A, FCGRT, FTH1, GPX4 +9 more	View in SCUBA
Gamma-delta T cells	Redox Stress Response Stress	BEX2, BEX4, CITED4, EEF1A1, FMNL3, GRINA, LTBP3, MICAL1 +5 more
Goblet cells	Co-translational Chaperone Protein processing & ER	ATP5MC2, BTF3, COMMD6, FTH1, HIGD2A, NACA, PFDN5, TOMM7	View in SCUBA
Innate lymphoid cells	Innate Inflammatory Activation Inflammation	ARL6IP5, BST2, CD2, CD63, HMGB1, ITM2B, MGST3, MTDH +7 more	View in SCUBA
Lymphatic endothelial	Translation Elongation RNA processing & translation	ANXA2, EEF1A1, EEF2, EIF1, FTH1, HNRNPA0, HNRNPA1, PTMA +2 more	View in SCUBA
Mucosal-associated invariant T cell	Translation Elongation RNA processing & translation	BAX, BTF3, COX4I1, EEF1B2, EEF1D, EIF3K, FAU, GPX4 +8 more
Neutrophils	Neutrophil Survival Program Inflammatory	B2M, BCL2A1, CEBPB, EIF1, FTH1, H3-3A, H3-3B, PNRC1 +2 more
Smooth muscle cells	Translation elongation housekeeping Housekeeping	COX4I1, EEF1A1, EEF1D, EEF2, FTH1, GAPDH, PTMA, RACK1 +4 more	View in SCUBA

About the gene

Synonyms	MGC71996, NBIA3
Chromosome	19: 48965309-48966879
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Biological process	Iron storage

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes by the cargo receptor NCOA4 for autophagic degradation and release or iron.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.