TGF-beta Response
Gene co-expression module in Glial cells
| Category | Inflammation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
BGN (biglycan) is an ECM proteoglycan upregulated in inflammation and fibrosis. PMEPA1 is a direct TGF-β/SMAD transcriptional target and negative feedback regulator. MEF2C is activated by inflammatory and stress signals in glia. TMSB4X sequesters actin during cytoskeletal remodeling. MPRIP regulates myosin phosphatase and actomyosin tension. CCDC85B modulates catenin signaling. The significant positive delta in UC inflammation and moderate coherence with some weak peripheral members suggest this module captures a TGF-β-driven inflammatory ECM response in enteric glia, distinct from the homeostatic collagen program of M64.
Genes
BGN, CCDC85B, DPP7, KCND3, MEF2C, MPRIP, PMEPA1, TMEM59L, TMSB4X, UBR4
Most correlated modules
- Oxidative Stress Response · correlation 0.85
- ER Stress Response · correlation 0.83
- Glial Adhesion Identity · correlation 0.81
- BMP-SMAD Signaling · correlation 0.79
- Peripheral Glial Myelination · correlation 0.79
- Reactive Glial Activation · correlation 0.77
- Glial Neural Scaffolding · correlation 0.75
- Hyaluronan-CD44 Remodeling · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.