Reactive Glial Activation
Gene co-expression module in Glial cells
| Category | Activation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
This module is strongly upregulated in both UC and CD inflammation (delta ~0.57 and ~0.28) and returns toward baseline at remission, indicating a robust inflammation-responsive program. Hub gene FAM20C is a Golgi-localized secretory pathway kinase that phosphorylates ECM proteins. CTSD (cathepsin D) is a lysosomal aspartic protease upregulated in reactive glia and inflammatory states. ANTXR1 is a cell-surface receptor linked to inflammatory signaling. PKM (pyruvate kinase M) reflects metabolic reprogramming. PTEN is a phosphatase regulating PI3K/AKT. GNG11 and SHC4 are signaling components. MAP1B is a microtubule-associated protein expressed in reactive glia. RASEF is a RAS-family GTPase. SLC25A6 is a mitochondrial carrier. Together the secretory kinase (FAM20C), lysosomal protease (CTSD), and cell-surface receptor (ANTXR1) suggest a reactive glial secretory/lysosomal activation program driven by intestinal inflammation.
Genes
ANP32B, ANTXR1, CTSD, FAM20C, GNG11, MAP1B, PKM, PTEN, RASEF, SHC4, SLC25A6
Most correlated modules
- Mitochondrial Housekeeping · correlation 0.89
- Proteostasis Stress Response · correlation 0.87
- RNA Translation Processing · correlation 0.84
- ER Translocon Activity · correlation 0.84
- ER Stress Response · correlation 0.82
- ER-Mitochondria Housekeeping · correlation 0.82
- Hyaluronan-CD44 Remodeling · correlation 0.82
- Oxidative Stress Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.