ER Stress Response
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes TAGLN2 (actin-binding, cytoskeletal), TPM4 (tropomyosin, actin filament), ANXA1 (annexin, membrane/cytoskeletal), HSPA5 (BiP/GRP78, ER chaperone), SERP1 (ER stress-associated), ARF4 (vesicular trafficking), SET (chromatin/PP2A), YWHAZ (14-3-3, signaling scaffold), RBM3 (cold-shock RNA-binding), CSNK1A1 (casein kinase), RAB32 (vesicle trafficking), SNRPG (spliceosome), KRT10 (keratin). The module mixes ER stress/chaperone genes (HSPA5, SERP1), cytoskeletal genes (TAGLN2, TPM4, ANXA1), and housekeeping/trafficking genes. HSPA5 and SERP1 are canonical ER stress markers; RBM3 is induced by mild stress and cold. The module is upregulated in UC and CD inflammation. The dominant ER stress signature combined with cytoskeletal remodeling is consistent with a glial stress/unfolded protein response program. Neighbor context: M51 shows strong inflammation-associated ECM/signaling genes; M20 is a weaker mixed module. Together they suggest a neighborhood of stress-responsive and adaptive programs in inflamed glia. The ER stress component (HSPA5, SERP1, ARF4, ANXA1, RBM3) is the most coherent sub-program.
Genes
ANXA1, ARF4, CSNK1A1, HSPA5, KRT10, RAB32, RBM3, SERP1, SET, SNRPG, TAGLN2, TPM4, YWHAZ
Most correlated modules
- RNA Translation Processing · correlation 0.92
- Mitochondrial Housekeeping · correlation 0.90
- ER Translocon Activity · correlation 0.89
- Actin Cytoskeletal Organization · correlation 0.88
- Proteostasis Stress Response · correlation 0.86
- Oxidative Stress Response · correlation 0.85
- Inflammatory Cytokine Signaling · correlation 0.84
- AHR-Cytokine Activation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.