Glial Neural Scaffolding
Gene co-expression module in Glial cells
| Category | Cytoskeletal |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
NFIX (Nuclear Factor I/X) is expressed in enteric and peripheral glia and neural progenitors, acting as a glial differentiation TF. AKAP6 is an A-kinase anchoring protein enriched in enteric nervous system neurons and glia, scaffolding cAMP/PKA signaling. SEMA6D is a semaphorin involved in axon guidance and neural circuit formation. PPP1R12B regulates myosin phosphatase/cytoskeletal tension. ARHGAP24 modulates Rho GTPase activity. COL5A3 links to the collagen neighborhood. Together these define a glial structural and neural signaling scaffolding program, neighbor to M64 via COL5A3.
Genes
AKAP6, ARHGAP24, COL5A3, EIF4G2, NFIX, PPP1R12B, SCAF11, SEMA6D, USP53
Most correlated modules
- Collagen ECM Deposition · correlation 0.85
- TGF-beta ECM Remodeling · correlation 0.83
- Glial Adhesion Identity · correlation 0.81
- AHR-Cytokine Activation · correlation 0.80
- TGF-beta Response · correlation 0.75
- Enteric Glial Identity · correlation 0.74
- Peripheral Glial Myelination · correlation 0.72
- Glial RNA Homeostasis · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.