Neuroprotective Secretory
Gene co-expression module in Glial cells
| Category | Neroprotection |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
TTR (transthyretin) is a secreted protein with well-established neuroprotective and antioxidant properties, expressed by choroid plexus and glial cells. SELENOP encodes selenoprotein P, a major selenium transporter with neuroprotective functions. TXNIP is a thioredoxin-interacting protein involved in redox homeostasis. IGFBP6 modulates IGF signaling. LRRTM1 is a synaptic leucine-rich repeat transmembrane protein. ANGPTL7 is involved in ECM and tissue homeostasis. PRELP is a proteoglycan linking ECM to cell surfaces. APCDD1 inhibits Wnt signaling. PDLIM2 is a PDZ-LIM scaffold. WDR86 is less characterized. The strongest inflammation delta of the batch (UC -1.058, CD -0.900, both significant), with strong remission recovery. TTR and SELENOP define a neuroprotective secretory program, consistent with glial protection of the enteric nervous system.
Genes
ANGPTL7, APCDD1, IGFBP6, LRRTM1, PDLIM2, PRELP, SELENOP, TTR, TXNIP, WDR86
Most correlated modules
- Glial Myelination Identity · correlation 0.84
- Myelinating Schwann Cell · correlation 0.83
- Matricellular ECM Homeostasis · correlation 0.80
- Neural Migration Scaffold · correlation 0.80
- Lysosomal Sphingolipid Metabolism · correlation 0.79
- Glial Synaptic Adhesion · correlation 0.77
- Enteric Glial Identity · correlation 0.77
- Glial Adhesion Cytoskeletal · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.