Glial Synaptic Adhesion
Gene co-expression module in Glial cells
| Category | Neroprotection |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include CADM2 (cell adhesion molecule, synaptic/glial contact), NRXN3 (neurexin, synaptic adhesion), SPTBN1 (spectrin beta, cytoskeletal scaffolding at membrane), PCDH9 (protocadherin, cell-cell recognition), GRIK3 (glutamate receptor, kainate type, expressed in enteric glia), AHNAK (large scaffold protein, membrane-cytoskeleton), ATP1A2 (Na/K-ATPase alpha-2, glial ion homeostasis), GATM (creatine biosynthesis, metabolic support), ASPH (aspartyl hydroxylase, calcium signaling), SREBF1 (lipid metabolism TF). The module is core-coherent, strongly downregulated in UC inflammation and restored at remission, suggesting a mature glial homeostatic program centered on cell adhesion, ion homeostasis, and synaptic-like glial contacts. Neighbor context (M48 also represents glial homeostasis) reinforces this interpretation.
Genes
AHNAK, ASPH, ATP1A2, CADM2, GATM, GRIK3, NRXN3, PCDH9, SPTBN1, SREBF1
Most correlated modules
- Glial Adhesion Cytoskeletal · correlation 0.89
- Glial Homeostatic Identity · correlation 0.85
- ECM Homeostatic Regulation · correlation 0.82
- Neural Migration Scaffold · correlation 0.82
- Matricellular ECM Homeostasis · correlation 0.82
- Cytoskeletal Glial Homeostasis · correlation 0.80
- Neuroprotective Secretory · correlation 0.77
- Peripheral Nerve Myelination · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.