NDRG2 — NDRG family member 2
NDRG2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NDRG2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | CAVIN2, CEACAM1, CYBA, DNMBP, EFCC1, EPHX1, GMFG, HID1 +7 more | View in SCUBA |
| Fibroblasts | Quiescent Anti-inflammatory Fibroblast Developmental | ADIRF, CHCHD10, DACH1, FXYD6, IGFBP3, KHDRBS3, LSP1, PDE1A +3 more | View in SCUBA |
| Glial cells | Enteric Glial Identity Activation | FAM181B, FIBIN, FXYD1, HTRA1, METTL7A, MRPS6, NKAIN3, PLEKHB1 +1 more | View in SCUBA |
About the gene
| Synonyms | KIAA1248, SYLD |
|---|---|
| Chromosome | 14: 21016763-21070872 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Neurogenesis, Wnt signaling pathway |
Function
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.