Epithelial Maturation
Gene co-expression module in Goblet cells
| Category | Epithelial development |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include STARD10 (lipid transfer/phospholipid metabolism), PHGR1 (intestinal epithelial marker), SI (sucrase-isomaltase, mature enterocyte brush border), AMN (cobalamin absorption receptor), NXPE4 (intestinal epithelial), PPDPF (secretory differentiation factor), and KRT10 (epithelial differentiation keratin). Together these mark mature intestinal epithelial differentiation, likely reflecting a mature/differentiated goblet cell state with some absorptive enterocyte gene co-expression. Moderate coherence and multiple weak-membership genes are consistent with a mixed differentiation signature. BAG1 co-chaperone links to the neighboring M91 heat shock module, suggesting these programs co-occur in resting mature epithelial cells.
Genes
AMN, BAG1, CDC42EP5, CST3, KRT10, NTRK2, NXPE4, PHGR1, PPDPF, SI, STARD10
Most correlated modules
- Notch Target Response · correlation 0.52
- Immediate Early Gene · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.