CDC42EP5 — CDC42 effector protein 5
CDC42EP5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDC42EP5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Redox Stress Response Stress | APEX1, ATP5F1E, ATP5MC1, EIF4EBP1, EPS8L1, MAGED1, MCFD2, MRPL12 +7 more | View in SCUBA |
| Enterocytes | Actin cytoskeleton Cytoskeletal | ACTB, ACTG1, CAST, CLDN7, JPT1, MYL12B, PIGR, TMEM54 | View in SCUBA |
| Glial cells | S100 Glial Activation Activation | CREB5, CRIP2, EMP3, S100A10, S100A4, S100A6, TPPP3 | View in SCUBA |
| Goblet cells | Epithelial Maturation Epithelial development | AMN, BAG1, CST3, KRT10, NTRK2, NXPE4, PHGR1, PPDPF +2 more | View in SCUBA |
About the gene
| Synonyms | Borg3, CEP5 |
|---|---|
| Chromosome | 19: 54465026-54473296 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell shape |
Function
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.