Notch Target Response
Gene co-expression module in Goblet cells
| Category | Epithelial development |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes NRARP and HES1 are canonical Notch pathway effectors — NRARP is a direct feedback inhibitor of Notch signaling and HES1 is the primary Notch transcriptional target. ID1 is BMP/Notch downstream. CLDN3 marks mature epithelial identity. KLF10 and GDF15 add TGF-β/stress context. The module is strongly downregulated in IBD inflammation and recovers in remission, consistent with loss of Notch-mediated goblet cell homeostasis during active disease. Neighbor to M96 which also contains HES4/HES5/NOTCH2, supporting a Notch neighborhood.
Genes
BRI3, CLDN3, GDF15, HES1, ID1, KLF10, NRARP, TRAF4
Most correlated modules
- Immediate Early Gene · correlation 0.78
- BMP Signaling Response · correlation 0.75
- Notch Secretory Specification · correlation 0.74
- Goblet Cell Differentiation · correlation 0.72
- NF-κB Stress Response · correlation 0.67
- Stress Chromatin Remodeling · correlation 0.61
- Co-translational Chaperone · correlation 0.60
- mRNA Stability Control · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.