Immediate Early Gene
Gene co-expression module in Goblet cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
All nine genes are canonical immediate early genes (IEGs) and AP-1 transcription factors: FOS, FOSB, JUNB, JUN, JUND form the AP-1 complex; EGR1 is a primary transcriptional response factor; DUSP1 is an IEG-induced MAPK phosphatase; BTG2 is an anti-proliferative IEG; IER2 is an immediate early response gene. This is a textbook IEG/AP-1 module, likely reflecting basal transcriptional activity and rapid responses to epithelial stimuli. Very high expression (97% positive). Neighbor M52 shares IEG character but with NF-κB stress flavor, confirming this batch neighborhood.
Genes
BTG2, DUSP1, EGR1, FOS, FOSB, IER2, JUN, JUNB, JUND
Most correlated modules
- NF-κB Stress Response · correlation 0.89
- Goblet Cell Differentiation · correlation 0.82
- Notch Target Response · correlation 0.78
- Stress Chromatin Remodeling · correlation 0.71
- Heat Shock Response · correlation 0.62
- BMP Signaling Response · correlation 0.62
- Epithelial Maturation · correlation 0.49
- Notch Secretory Specification · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.