KRT10 — Keratin 10
KRT10 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KRT10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Chronic Inflammatory Activation Inflammation | ABL2, ADAMTS9, DDX21, EMP1, FOSL2, HRH1, LMNA, PNP +2 more | View in SCUBA |
| Glial cells | ER Stress Response Stress | ANXA1, ARF4, CSNK1A1, HSPA5, RAB32, RBM3, SERP1, SET +4 more | View in SCUBA |
| Goblet cells | Epithelial Maturation Epithelial development | AMN, BAG1, CDC42EP5, CST3, NTRK2, NXPE4, PHGR1, PPDPF +2 more | View in SCUBA |
| Innate lymphoid cells | Pre-mRNA Splicing RNA processing & translation | AAK1, CDC42SE2, CIB1, DDX46, HNRNPM, KTN1, LARP7, LYRM2 +3 more | View in SCUBA |
| Macrophages | Low-Coherence Mixed Technical artifact | AAMP, ALKBH7, CDC123, COMMD5, DNTTIP1, EIF3G, EIF4E2, FAM32A +8 more | View in SCUBA |
About the gene
| Synonyms | CK10, K10, KPP |
|---|---|
| Chromosome | 17: 40818117-40822614 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium (By similarity). (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.