Mucin Glycosylation Remodeling
Gene co-expression module in Goblet cells
| Category | Mucus production & secretion |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include B3GNT6 and ST3GAL4 (mucin glycosylation enzymes), GALE (sugar nucleotide interconversion), PARM1 (mucin-like protein), FFAR4 (short-chain fatty acid receptor sensing microbiome metabolites), SERPINA1 (protease inhibitor), and ASS1 (arginine metabolism). The module is strongly upregulated in UC and CD inflammation and reverses in remission, consistent with an adaptive inflammatory response in goblet cells. The glycosylation genes dominate the functional signature, supported by metabolic genes. This reflects goblet cell mucin glycosylation remodeling during intestinal inflammation.
Genes
ASS1, B3GNT6, DNAJC12, FFAR4, GALE, PARM1, SERPINA1, ST3GAL4
Most correlated modules
- Goblet Secretory Identity · correlation 0.87
- Actin Cytoskeletal Remodeling · correlation 0.85
- S100 Calcium Signaling · correlation 0.84
- ER Chaperone Glycosylation · correlation 0.82
- Golgi-Exocytosis Machinery · correlation 0.80
- Protein trafficking & glycosylation · correlation 0.79
- Inflammatory goblet response · correlation 0.78
- N-Glycosylation ER Stress · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.