SERPINA1 — Serpin family A member 1
SERPINA1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SERPINA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Surface colonocyte lipid-droplet Lipid metabolism | ALPI, CDKN1A, CIDEB, CIDEC, IL32, LMO7, LPGAT1, MPP1 +4 more | View in SCUBA |
| Goblet cells | Mucin Glycosylation Remodeling Mucus production & secretion | ASS1, B3GNT6, DNAJC12, FFAR4, GALE, PARM1, ST3GAL4 | View in SCUBA |
| Macrophages | Oxidative Metabolic Program Mitochondrial & OxPhos | ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 more | View in SCUBA |
| Monocytes | Myeloid Innate Receptor Signaling Innate immunity | CYTIP, HCK, JPT1, LILRA5, LILRB2, MYD88, PAG1, PILRA | View in SCUBA |
| Neutrophils | Phagocytic Membrane Signaling Phagocytosis | APLP2, ATP6V1B2, CD44, CDC42EP3, CLIC1, EFHD2, FCER1G, FLOT1 +9 more |
About the gene
| Synonyms | A1A, A1AT, AAT, alpha-1-antitrypsin, alpha1AT, PI, PI1 |
|---|---|
| Chromosome | 14: 94376747-94390693 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Protease inhibitor, Serine protease inhibitor |
| Biological process | Acute phase, Blood coagulation, Hemostasis |
Function
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.