ER Chaperone Glycosylation
Gene co-expression module in Goblet cells
| Category | Protein processing & ER |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
PPIC and FKBP2 are ER peptidyl-prolyl isomerases (chaperones); OST4 is an oligosaccharyltransferase subunit (N-glycosylation); NANS synthesizes sialic acid (O/N-glycan terminal sugar); TMED3 and RABAC1 mediate vesicle trafficking; REEP5 shapes ER membranes; ANG is a secreted RNase; CD63 marks secretory lysosomes; SLC1A5 supplies glutamine for biosynthesis. Neighbor to M88/M31 with shared ER/Golgi theme but emphasizing ER chaperone folding and glycan modification rather than ERAD or co-translational targeting.
Genes
ANG, ATP6V1G1, CD63, FKBP2, NANS, OST4, PPIC, RABAC1, REEP5, SERF2, SLC1A5, TCEA3, TMED3
Most correlated modules
- Mucin Folding Machinery · correlation 0.91
- Goblet Secretory Identity · correlation 0.89
- N-Glycosylation ER Stress · correlation 0.88
- UPR Chaperone Response · correlation 0.85
- ER Protein Translocation · correlation 0.83
- Mucin Glycosylation Remodeling · correlation 0.82
- ER Targeting ERAD · correlation 0.82
- Protein trafficking & glycosylation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.