Inflammatory goblet response
Gene co-expression module in Goblet cells
| Category | Immune function |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
TFF1 (trefoil factor 1, goblet/foveolar mucosa repair), MUC13 (transmembrane mucin), LYPD8 (luminal mucosal defense glycoprotein), CAPN8 (gastric/foveolar calpain), B4GALT1 (glycosylation of mucins), KRT20 (colonocyte/goblet marker), CEACAM6 (IBD-associated glycoprotein), SELENOP (selenium/anti-oxidant in mucosa), ANXA1 (anti-inflammatory annexin), DST (dystonin/cytoskeleton). All genes are core-membership. Strikingly upregulated in UC inflammation (delta=1.086) and almost completely reversed in UC remission (delta=-0.913), indicating this is an inflammation-reactive goblet program. TFF1, MUC13, LYPD8, CAPN8 together mark a stressed/reactive goblet mucosa-defense state.
Genes
ANXA1, B4GALT1, CAPN8, CEACAM6, DST, KRT20, LYPD8, MUC13, MXD1, PLAC8, SDCBP2, SDR16C5, SELENOP, SPATS2L, SPNS2, TFF1, TRIM31
Most correlated modules
- Actin Cytoskeletal Remodeling · correlation 0.81
- Mucin Glycosylation Remodeling · correlation 0.78
- Basement Membrane Remodeling · correlation 0.78
- S100 Calcium Signaling · correlation 0.77
- DUOX2 Epithelial Inflammation · correlation 0.77
- MHC Class I Antigen Presentation · correlation 0.66
- Golgi-Exocytosis Machinery · correlation 0.61
- Mucosal Antibacterial Defense · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.