S100 Calcium Signaling
Gene co-expression module in Goblet cells
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
Five S100 family members (S100A6, S100A11, S100A13, S100A14, S100A16) plus S100P dominate the module — these are calcium-binding alarmins upregulated in epithelial inflammation. CIB1 is another calcium/integrin-binding protein. RHOC and MYL12B/MYL6 link to actomyosin contractility downstream of calcium signaling. CLDN7 supports epithelial identity. All genes are core/strong members with uniform expression. Upregulated in IBD inflammation. The module represents calcium-alarmin signaling in inflamed goblet/epithelial cells.
Genes
CIB1, CLDN7, CLTB, GUK1, MYL12B, MYL6, RHOC, S100A11, S100A13, S100A14, S100A16, S100A6, S100P
Most correlated modules
- Actin Cytoskeletal Remodeling · correlation 0.84
- Mucin Glycosylation Remodeling · correlation 0.84
- Metabolic Stress Response · correlation 0.79
- ER Chaperone Glycosylation · correlation 0.78
- Inflammatory goblet response · correlation 0.77
- Mucosal Antibacterial Defense · correlation 0.77
- Basement Membrane Remodeling · correlation 0.71
- ER Protein Processing · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.