Golgi-Exocytosis Machinery
Gene co-expression module in Goblet cells
| Category | Mucus production & secretion |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
GOLGA2 (GM130) and GOLGA3 (Golgin-245) are Golgi matrix tethering proteins essential for Golgi ribbon structure. SEC31A is a COPII outer coat component for ER exit. MIA3/TANGO1 mediates ER export of large cargo including mucins and procollagen. GALNT5 adds O-GalNAc to mucins. MLPH (melanophilin) and SYTL2 (synaptotagmin-like 2) are Rab27a effectors that dock and fuse secretory granules at the plasma membrane. TMF1 is a Golgi tethering factor. RRBP1 anchors ribosomes to ER membranes for co-translational import of secretory proteins. PLA2G10 is a secreted enzyme. Together this module captures Golgi structural integrity, ER-to-Golgi transport, and secretory granule exocytosis — the machinery for goblet cell mucin granule release.
Genes
BCAS1, GALNT5, GOLGA2, GOLGA3, MIA3, MLPH, PLA2G10, RRBP1, SEC31A, SYTL2, TMF1
Most correlated modules
- Protein trafficking & glycosylation · correlation 0.88
- N-Glycosylation ER Stress · correlation 0.87
- Goblet Secretory Identity · correlation 0.85
- ER Targeting ERAD · correlation 0.85
- Mucin O-Glycosylation · correlation 0.82
- Mucin Glycosylation Remodeling · correlation 0.80
- ER Chaperone Glycosylation · correlation 0.78
- Actin Cytoskeletal Remodeling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.