Actin Cytoskeletal Remodeling
Gene co-expression module in Goblet cells
| Category | Cytoskeletal |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes TPM4, ACTR3, ACTN4, CAP1 define actin cytoskeletal remodeling; FHL2 and SDCBP link cytoskeleton to adhesion/membrane; SLC7A11 (xCT) adds oxidative stress defense (ferroptosis resistance); BHLHE40 is a stress-responsive transcription factor. The module is strongly upregulated in UC/CD inflammation and reverses in UC remission, consistent with cytoskeletal stress remodeling in inflamed goblet cells. Neighbor context: M82 contains RHOC and myosin light chains, confirming a cytoskeletal neighborhood.
Genes
ACTN4, ACTR3, BHLHE40, CAP1, FHL2, KCNK1, LRP10, SDCBP, SLC7A11, TCIM, TMEM167A, TPM4
Most correlated modules
- Mucin Glycosylation Remodeling · correlation 0.85
- S100 Calcium Signaling · correlation 0.84
- Inflammatory goblet response · correlation 0.81
- Metabolic Stress Response · correlation 0.81
- ER Targeting ERAD · correlation 0.80
- Basement Membrane Remodeling · correlation 0.80
- Protein trafficking & glycosylation · correlation 0.80
- Hypoxia Metabolic Stress · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.