Epithelial Junction Integrity
Gene co-expression module in Goblet cells
| Category | migration & adhesion |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
DSC2 (desmocollin-2) and PERP are desmosomal components; CTNNA1 (α-catenin) is a core adherens junction protein. ANXA2 (annexin A2) links actin to the plasma membrane and participates in exocytosis and junction maintenance. ACTR2 (Arp2) nucleates branched actin. SERPINB1 protects epithelial cells from neutrophil serine proteases during inflammation. TNFSF10/TRAIL is a death ligand that can drive apoptosis in barrier cells. GLUL (glutamine synthetase) contributes to epithelial metabolic function. The module moderate coherence and mild inflammation response suggest constitutive epithelial barrier/junction maintenance with some apoptotic signaling. The desmosome/AJ genes are the most coherent functional subgroup. Neighbor M45 shares cytoskeletal/homeostasis elements, consistent with both being constitutive epithelial structural programs.
Genes
ACTR2, ANXA2, CTNNA1, DSC2, GLUL, PERP, SERPINB1, TNFSF10
Most correlated modules
- Ubiquitin Protein Homeostasis · correlation 0.68
- Adhesion & Transport · correlation 0.65
- Basement Membrane Remodeling · correlation 0.53
- MHC Class I Antigen Presentation · correlation 0.53
- Epithelial Membrane Identity · correlation 0.48
- EGF-Driven Wound Repair · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.