EGF-Driven Wound Repair
Gene co-expression module in Goblet cells
| Category | Epithelial development |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
AREG (amphiregulin) and HBEGF are EGF-family wound-healing ligands classically upregulated in epithelial repair. CXCL8 (IL-8) is a hallmark inflammatory chemokine. RHPN2 and RAP2B support cytoskeletal/Rho signaling in migration. VASP links to actin-based motility. F11R (JAM-A) supports epithelial junction remodeling. NCOA7 is an ISG/stress coactivator. HBEGF+AREG+CXCL8 as co-expressed hub genes strongly indicate an EGF-driven wound-healing inflammatory response. The module is modestly upregulated in CD inflammation and notably elevated in remission, consistent with a repair/restitution program.
Genes
AREG, ARL14, C3orf52, CXCL8, F11R, HBEGF, NCOA7, RAP2B, RHPN2, VASP
Most correlated modules
- Stress Survival Response · correlation 0.90
- Basement Membrane Remodeling · correlation 0.85
- Hypoxia Metabolic Stress · correlation 0.81
- Actin Cytoskeletal Remodeling · correlation 0.72
- Stress Chromatin Remodeling · correlation 0.60
- Inflammatory goblet response · correlation 0.54
- Mucosal Antibacterial Defense · correlation 0.53
- NF-κB Stress Response · correlation 0.52
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.