Adhesion & Transport
Gene co-expression module in Goblet cells
| Category | Cytoskeletal |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub gene ITGB1 (integrin beta-1) anchors a cell-matrix adhesion program. TES (tessin) is a focal adhesion LIM domain protein co-regulated with ITGB1. DYNC1LI2 and DYNC1H1 are dynein motor complex subunits mediating intracellular vesicle and organelle transport. CHMP1B is an ESCRT-III component for endosomal sorting. VIL1 (villin) is an actin-bundling protein of the brush border/cytoskeleton. YWHAE (14-3-3ε) scaffolds multiple signaling complexes. EIF4G2 and DDX5 contribute translation/RNA processing. The module is minimally changed with inflammation, consistent with a constitutive structural/cytoskeletal program. The combination of adhesion (ITGB1, TES), transport (DYNC1LI2, DYNC1H1, CHMP1B), and cytoskeletal (VIL1) genes defines intracellular transport and adhesion.
Genes
AHCYL1, CHMP1B, DDX5, DYNC1H1, DYNC1LI2, EIF4G2, ITGB1, PTTG1IP, SLC38A1, TES, TOP1, VIL1, YWHAE
Most correlated modules
- Chromatin Remodeling · correlation 0.83
- Ion Transport Homeostasis · correlation 0.81
- Chromatin Remodeling · correlation 0.79
- Epithelial Maintenance · correlation 0.76
- Chromatin RNA Regulation · correlation 0.69
- Nuclear Architecture · correlation 0.68
- Lipid Redox Homeostasis · correlation 0.67
- RNA Decay Processing · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.