Ubiquitin Protein Homeostasis
Gene co-expression module in Goblet cells
| Category | Housekeeping |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Moderate coherence with many weak/moderate membership genes. CSNK1A1 participates in the β-catenin destruction complex (WNT pathway). UBE2D3 is a ubiquitin E2 enzyme for proteasomal degradation. TAX1BP1 is a selective autophagy receptor that also attenuates NF-κB. CMTM6 stabilizes PD-L1 on the cell surface. YWHAZ (14-3-3ζ) is a broad signaling scaffold. MORF4L1 is a chromatin regulator (NuRF/MORF complex). KIF5B is a kinesin involved in organelle transport. ARPC2 is an Arp2/3 actin nucleation component. TMBIM6 is an anti-apoptotic ER membrane protein. The minimal inflammation response and moderate coherence suggest a constitutive housekeeping program combining ubiquitin-mediated protein turnover with general cellular homeostasis. No single tight pathway emerges; closest theme is ubiquitin/proteasome-mediated protein homeostasis.
Genes
ARPC2, BZW1, CMTM6, CSNK1A1, DAP, EMP2, GNAI3, KIF5B, MORF4L1, RTN4, SARAF, TAX1BP1, TMBIM6, UBE2D3, YWHAZ
Most correlated modules
- Mucin O-Glycosylation · correlation 0.74
- Epithelial Junction Integrity · correlation 0.68
- Protein trafficking & glycosylation · correlation 0.68
- ER Protein Translocation · correlation 0.67
- ER Protein Processing · correlation 0.65
- Ubiquitin-Proteasome Degradation · correlation 0.63
- Basal Transcription · correlation 0.62
- Adhesion & Transport · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.