ER Protein Translocation
Gene co-expression module in Goblet cells
| Category | Protein processing & ER |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes TMED2/TMED10 (COPI cargo receptors/p24 family), SSR1 (translocon-associated protein), LMAN1 (ERGIC-53 ER-Golgi lectin), SPCS2/3 (signal peptidase complex), RPN2 (oligosaccharyltransferase), PDIA6 (ER oxidoreductase), DNAJC3 (ER co-chaperone) all function in cotranslational protein import into the ER, signal peptide cleavage, N-glycosylation, and ER-to-Golgi cargo selection. Core coherence, uniform goblet expression, upregulated in UC inflammation with remission reversal. Neighbor modules M70 and M13 confirm a broader ER protein processing neighborhood.
Genes
DNAJC3, LMAN1, PDIA6, RPN2, SPCS2, SPCS3, SSR1, TMED10, TMED2
Most correlated modules
- Mucin Folding Machinery · correlation 0.94
- UPR Chaperone Response · correlation 0.93
- N-Glycosylation ER Stress · correlation 0.90
- Mucin O-Glycosylation · correlation 0.89
- ERAD ER Homeostasis · correlation 0.88
- Protein trafficking & glycosylation · correlation 0.87
- ER Targeting ERAD · correlation 0.86
- ER Chaperone Glycosylation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.