UPR Chaperone Response
Gene co-expression module in Goblet cells
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
CRELD2, MANF, SDF2L1 are canonical PERK/IRE1 UPR target genes. PDIA4, P4HB (PDIA1), PDIA3, CALR are ER chaperones/PDIs. NUCB2 is an ER/Golgi Ca2+-binding protein. RPN1 is part of the OST complex. All core membership. Strongly upregulated in both UC and CD inflammation, reversed in UC remission. This represents the classical ER stress/UPR chaperone response, distinguished from neighbor M92 (translocon machinery) by its focus on protein folding quality control and UPR induction.
Genes
CALR, CRELD2, GMPPB, LRRC59, MANF, NUCB2, P4HB, PDIA3, PDIA4, RPN1, SDF2L1
Most correlated modules
- Mucin Folding Machinery · correlation 0.94
- ER Protein Translocation · correlation 0.93
- N-Glycosylation ER Stress · correlation 0.91
- ER Targeting ERAD · correlation 0.87
- ERAD ER Homeostasis · correlation 0.87
- Metabolic Stress Response · correlation 0.86
- ER Chaperone Glycosylation · correlation 0.85
- Protein trafficking & glycosylation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.