Mucin Folding Machinery
Gene co-expression module in Goblet cells
| Category | Mucus production & secretion |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
SEC61B and SEC61G encode the core translocon channel subunits. OSTC is part of the oligosaccharyltransferase complex. SSR3 is translocon-associated. SEC11C is signal peptidase. PPIB (cyclophilin B) is an ER peptidyl-prolyl isomerase for proline-rich proteins. KDELR2 retrieves ER-resident proteins from Golgi. AGR2 is a goblet-cell-specific ER protein disulfide isomerase essential for MUC2 folding. MYDGF is an ER-secreted protein. All core membership, highest mean expression (1.47) and pct positive (90%) in the batch. This represents the core ER protein processing machinery with goblet-specific emphasis on mucin folding via AGR2.
Genes
AGR2, KDELR2, MYDGF, OSTC, PPIB, SEC11C, SEC61B, SEC61G, SSR3
Most correlated modules
- UPR Chaperone Response · correlation 0.94
- ER Protein Translocation · correlation 0.94
- ERAD ER Homeostasis · correlation 0.92
- ER Chaperone Glycosylation · correlation 0.91
- N-Glycosylation ER Stress · correlation 0.91
- ER Targeting ERAD · correlation 0.88
- Goblet Secretory Identity · correlation 0.84
- Mucin O-Glycosylation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.