RNASEH2B — Ribonuclease H2 subunit B
RNASEH2B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNASEH2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitoribosome Small Subunit Mitochondrial & OxPhos | ACADM, C14orf119, CHCHD1, COA3, COA4, COMMD8, GALK1, GEMIN6 +24 more | |
| Hematopoietic progenitor cells | Lymphoid Progenitor TFs Lymphcyte development | ADAM28, AFF3, ANKRD44, CYFIP2, CYLD, HLA-DMB, MEF2C, PDE7A +4 more | |
| Macrophages | Ribosome Biogenesis Cell cycle | ACAT1, ANAPC5, CFDP1, IKBIP, MGME1, MGMT, NAA15, NAA25 +8 more | View in SCUBA |
About the gene
| Synonyms | AGS2, DLEU8, FLJ11712 |
|---|---|
| Chromosome | 13: 50909747-51024120 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.