Myeloid Immune Checkpoint
Gene co-expression module in Macrophages
| Category | Innate immunity |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
CD276 (B7-H3, immune checkpoint ligand expressed on myeloid cells) is the dominant hub. CLEC12A (myeloid inhibitory C-type lectin receptor), ITGAL (LFA-1/CD11a, leukocyte adhesion and immune synapse), LIMK1 (LIM kinase, actin dynamics downstream of Rho), SORT1 (sortilin, lysosomal/endosomal trafficking), SPINT1 (serine protease inhibitor). The combination of CD276 and CLEC12A points to myeloid immune checkpoint/inhibitory signaling. Small module with weak coherence limits confidence.
Genes
CD276, CLEC12A, ITGAL, LIMK1, SELENON, SLC27A3, SORT1, SPINT1
Most correlated modules
- ER-Lysosome Trafficking · correlation 0.91
- Monocyte Phagocytic Identity · correlation 0.91
- Oxidative Metabolic Program · correlation 0.91
- Fc Receptor Phagocytosis · correlation 0.88
- SPP1 Tissue Remodeling · correlation 0.87
- Inflammatory Monocyte Activation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.