Oxidative Metabolic Program
Gene co-expression module in Macrophages
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 38 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
GOT2 (aspartate aminotransferase, TCA cycle/malate-aspartate shuttle), ACADM (fatty acid beta-oxidation), HSD17B4 (peroxisomal fatty acid oxidation), CRLS1-neighbor LDHA (glycolysis), GSN (gelsolin, actin remodeling), ITGB2 (integrin beta-2, leukocyte adhesion), CALM3 (calmodulin, calcium signaling), EIF4EBP1 (mTOR/translation), IFI27L2 (ISG). The module is weakly coherent and heterogeneous. The strongest metabolic theme involves mitochondrial/oxidative metabolism (GOT2, ACADM, HSD17B4). Neighbor to M71 which has a tissue-remodeling program. This likely reflects a general macrophage metabolic housekeeping state.
Genes
ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D, EIF4EBP1, ENOPH1, GOT2, GPS1, GSN, HCFC1R1, HSD17B4, IFI27L2, ITGB2, JOSD2, LDHA, LGALS1, METTL26, PEA15, PFKP, PGM2, PNPO, PPDPF, PPT1, SCD, SCPEP1, SELENOW, SERPINA1, SH3BGRL3, SLAMF8, SMIM30, SRD5A3, TLR8, TUBA1A, ZDHHC24
Most correlated modules
- Glycolytic Metabolism · correlation 0.96
- Glycogen Metabolism · correlation 0.94
- Fc Receptor Phagocytosis · correlation 0.93
- Monocyte Phagocytic Identity · correlation 0.92
- Myeloid Immune Checkpoint · correlation 0.91
- Complex I / NADH Dehydrogenase · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.