SELENON — Selenoprotein N
SELENON belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SELENON's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Lymphatic Vascular Stability endothelial development | GJA1, GLT8D2, HIC1, HSD17B12, IGFBP4, KCTD12, MAF, ROBO4 +6 more | View in SCUBA |
| Macrophages | Myeloid Immune Checkpoint Innate immunity | CD276, CLEC12A, ITGAL, LIMK1, SLC27A3, SORT1, SPINT1 | View in SCUBA |
| Pericytes | Vascular Junction Adhesion Migration & adhesion | ABHD17A, CCDC85B, CDC37, ESAM, FYN, HECW2, PREX1, SLC44A2 +2 more | View in SCUBA |
About the gene
| Synonyms | MDRS1, RSMD1, RSS, SELN, SEPN1 |
|---|---|
| Chromosome | 1: 25800193-25818221 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity. Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation. Essential for muscle regeneration and satellite cell maintenance in skeletal muscle
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.