ER-Lysosome Trafficking
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 30 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include EMC10 (ER membrane complex), TMED10 (COPI vesicle trafficking), NCSTN (gamma-secretase/Notch), LAMP1/LAMP2 (lysosomal membrane), RPN1 (ER N-glycosylation), LMAN1 (ER-Golgi cargo receptor), GNS (lysosomal sulfatase), TMBIM1 (lysosomal membrane protein), NCEH1 (lysosomal cholesterol esterase), OSTM1 (lysosomal). The module spans the ER-to-Golgi-to-lysosome trafficking axis, consistent with vesicular trafficking in mono_mac macrophages. SIRPA and LAMP2 further support myeloid lysosomal identity.
Genes
BPNT2, CALU, CLPTM1L, CTSB, DHRS7, EMC10, GBA1, GNS, GPNMB, HSD17B12, LAMP1, LAMP2, LMAN1, MSN, NCEH1, NCSTN, OSTM1, PIGT, PNPLA6, RPN1, SEC23B, SIRPA, SLC25A24, SMPD1, SYPL1, TIMP2, TMBIM1, TMED10, VAT1, ZMPSTE24
Most correlated modules
- ER Protein Quality Control · correlation 0.96
- Glycogen Metabolism · correlation 0.96
- Monocyte Phagocytic Identity · correlation 0.95
- ER Membrane Homeostasis · correlation 0.95
- Autophagy Vesicular Trafficking · correlation 0.95
- Monocyte-Mac Iron Transport · correlation 0.94
- Central Carbon Metabolism · correlation 0.94
- Phagocytic Endolysosomal · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.