Inflammatory Monocyte Activation
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 30 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 15 of 20 genes have a known function matching the annotation |
Why this annotation
Multiple S100 family members (S100A4, S100A6, S100A9, S100A10) are canonical inflammatory monocyte/macrophage markers. NCF2 (NADPH oxidase component, oxidative burst), LTA4H (leukotriene A4 hydrolase, eicosanoid synthesis), TSPO (mitochondrial translocator protein, inflammatory), OSCAR (osteoclast-associated receptor, myeloid activation), ANXA2 (annexin A2, inflammatory signaling), HK2 (hexokinase 2, Warburg/inflammatory metabolism), RHOC (Rho GTPase, migration), VIM (vimentin, mesenchymal/inflammatory), ERO1A (ER oxidative stress), DRAM1 (damage-regulated autophagy). Strong mono_mac enrichment throughout. This is a classical inflammatory monocyte-derived macrophage activation program.
Genes
ACTN1, ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9, DRAM1, ERO1A, GSDME, HK2, ITGAX, LTA4H, NCF2, OSCAR, PAPSS1, RHOC, S100A10, S100A4, S100A6, S100A9, SDC4, SGTB, SLC39A13, SNX10, SQOR, TGM2, TSPO, VIM
Most correlated modules
- SPP1 Tissue Remodeling · correlation 0.92
- Phagocytic Endolysosomal · correlation 0.92
- Hypoxia Stress Response · correlation 0.91
- Hypoxia-driven Activation · correlation 0.89
- Monocyte Innate Signaling · correlation 0.89
- Monocyte Phagocytic Identity · correlation 0.85
- Myeloid Immune Checkpoint · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.