SPINT1 — Serine peptidase inhibitor, Kunitz type 1
SPINT1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPINT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | ER-autophagy homeostasis Protein processing & ER | AQP11, CCSER2, CTSD, MFSD2A, PLOD2, RB1CC1, REEP3, RESF1 +1 more | View in SCUBA |
| Macrophages | Myeloid Immune Checkpoint Innate immunity | CD276, CLEC12A, ITGAL, LIMK1, SELENON, SLC27A3, SORT1 | View in SCUBA |
About the gene
| Synonyms | HAI, HAI-1, MANSC2 |
|---|---|
| Chromosome | 15: 40844018-40858207 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Molecular function | Protease inhibitor, Serine protease inhibitor |
Function
Inhibitor of HGFAC. Inhibits serine protease activity of ST14/matriptase in vitro. Inhibits serine protease activity of TMPRSS13, via the BPTI/Kunitz inhibitor 1 domain.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.