SORT1 — Sortilin 1
SORT1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SORT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Homeostasis Endothelial cell development | ATP2A3, ATP6V1C2, C19orf33, CP, EMP3, ICAM2, MERTK, PLLP +5 more | View in SCUBA |
| Macrophages | Myeloid Immune Checkpoint Innate immunity | CD276, CLEC12A, ITGAL, LIMK1, SELENON, SLC27A3, SPINT1 | View in SCUBA |
| Neutrophils | Apoptotic Neutrophil Program Developmental | ANO10, APAF1, ARFGEF1, ATF7IP, BLTP1, CEP350, FAR2, FBXW2 +5 more | |
| Smooth muscle cells | Actomyosin Regulation Contractility | ARID5A, ASAH1, CAP2, COX6A2, DMTN, GABRA4, HAPLN2, NAPA +6 more | View in SCUBA |
About the gene
| Synonyms | Gp95, NT3 |
|---|---|
| Chromosome | 1: 109309568-109397918 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Developmental protein, Receptor |
| Biological process | Differentiation, Endocytosis, Osteogenesis, Transport |
Function
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.