Cytoskeletal Remodeling
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub gene F2RL3 (PAR4, protease-activated receptor 4) mediates thrombin/coagulation signaling in pericytes and vascular cells. FSCN1 (fascin) is an actin-bundling protein driving filopodial/lamellipodial dynamics and cell migration. ARHGAP18 is a Rho GAP regulating cytoskeletal tension and cell shape. TBCD (tubulin-specific chaperone D) is required for tubulin folding and microtubule assembly. IVNS1ABP binds actin. VWA1 is an ECM protein with von Willebrand A domain. SEMA3F provides repulsive axon/vascular guidance. JUP (junction plakoglobin) maintains cell-cell junctions. Together these define a cytoskeletal remodeling and migratory program in pericytes, with thrombin-PAR4 signaling as a potential upstream trigger. Unlike neighbors, this module is not significantly inflammation-responsive, suggesting a more constitutive or injury-independent program.
Genes
ARHGAP18, F2RL3, FSCN1, IVNS1ABP, JUP, PASK, SEMA3F, TBCD, VWA1
Most correlated modules
- Basement Membrane Maintenance · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.