TBCD — Tubulin folding cofactor D

TBCD belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TBCD's module in each cell type

Cell type	Module	Shares the module with
CD8⁺ T cells	Cytotoxic Gut Effector cytotoxicity	ATP8B4, CCND2, CD63, CEBPB, CSF1, CTSA, GNLY, GNPTAB +3 more	View in SCUBA
Endothelial	Coagulation Protease Signaling Inflammation	CFDP1, F2RL3, FRMD8, HTRA1, ITIH5, ME3, PASK, PRSS23 +1 more	View in SCUBA
Pericytes	Cytoskeletal Remodeling Cytoskeletal	ARHGAP18, F2RL3, FSCN1, IVNS1ABP, JUP, PASK, SEMA3F, VWA1	View in SCUBA

About the gene

Chromosome	17: 82752042-82945914
Predicted location	Intracellular, Membrane
Essential gene	Yes
Protein class	Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Chaperone, GTPase activation

Function

Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.