Pericyte Identity
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes CLMN (actin-binding pericyte marker), ADIRF (smooth muscle/pericyte identity factor), TINAGL1 (basement membrane ECM glycoprotein), FRMD3 (FERM domain cytoskeletal anchor), and GPX3 (secreted antioxidant) collectively define a quiescent pericyte identity program. Core coherence and uniform expression across subsets confirm a stable cell-state identity module. Decreased expression in UC inflammation suggests loss of pericyte quiescence during active disease. Neighbor M79 encodes the contractile apparatus of the same cell type, supporting a pericyte identity interpretation.
Genes
ADIRF, CLMN, FRMD3, GPX3, HIGD1B, KLHL23, MAP3K20, PLCE1, TINAGL1
Most correlated modules
- Pericyte Identity Differentiation · correlation 0.57
- Pericyte ECM Secretion · correlation 0.54
- Smooth Muscle Contractile · correlation 0.51
- Myosin Phosphatase Regulation · correlation 0.48
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.