Smooth Muscle Contractile
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
MYH11 (smooth muscle myosin heavy chain), PLN (phospholamban, SERCA regulator), SYNM (synemin intermediate filament), PALLD (palladin actin scaffold), NET1 (RhoA GEF driving actomyosin contractility), RERGL (smooth muscle RAS-like GTPase), ZFHX3 (smooth muscle differentiation TF), and NRGN (calmodulin-binding) collectively define the contractile smooth muscle/pericyte program. Strong coherence and uniform expression confirm a tight contractile identity module. This module is a topological neighbor of M16 (pericyte quiescence/identity), together representing complementary aspects of mature mural cell identity.
Genes
GPRC5C, MYH11, NET1, NRGN, PALLD, PLN, RERGL, SYNE1, SYNM, TSC22D1, ZFHX3
Most correlated modules
- Myosin Phosphatase Regulation · correlation 0.71
- Pericyte Identity · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.