Myosin Phosphatase Regulation
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
PPP1R12A and PPP1R12B encode the myosin phosphatase targeting subunits MYPT1 and MYPT2, which regulate smooth muscle contractility. CALM2 (calmodulin) and CRYAB (alphaB-crystallin, a small heat shock protein stabilizing cytoskeletal elements) support actomyosin regulation. LBH is a transcription factor active in smooth muscle/pericyte differentiation. JAG1 (Notch ligand) is expressed in pericytes and regulates vascular tone. CRIP1 is a LIM-domain protein in smooth muscle. Together these define a myosin phosphatase / contractility regulatory module in pericytes.
Genes
CALM2, CRIP1, CRYAB, HCFC1R1, JAG1, LBH, MAP3K7CL, PHLDA2, PLAC9, PPP1R12A, PPP1R12B
Most correlated modules
- Smooth Muscle Contractile · correlation 0.84
- Quiescent Pericyte State · correlation 0.78
- Pericyte Vascular Tone · correlation 0.72
- Smooth Muscle Contractile · correlation 0.71
- Focal Adhesion Cytoskeleton · correlation 0.71
- Actin Dynamics · correlation 0.70
- Hypoxia NO Signaling · correlation 0.60
- Pericyte Identity · correlation 0.48
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.