Pericyte Vascular Tone
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include CSPG4/NG2 (the most canonical pericyte surface proteoglycan), MCAM/CD146 (pericyte marker), FOXS1 (transcription factor enriched in pericytes), LINGO1 (leucine-rich repeat, expressed in pericytes/neural), MFGE8 (milk fat globule EGF factor 8, pericyte/vascular), PGF (placental growth factor, VEGF family, angiogenesis), PTGIR (prostacyclin receptor IP, vascular tone regulation in pericytes), SOD3 (extracellular superoxide dismutase, vascular), TBX2 (TF), RASGRP2, ADAP2, CHCHD10. CSPG4+MCAM+FOXS1+PTGIR+MFGE8 define a pericyte vascular tone/identity program distinct from M5's PDGFRB/NOTCH3 program.
Genes
ADAP2, CHCHD10, CSPG4, FOXS1, LINGO1, MCAM, MFGE8, PGF, PTGIR, RASGRP2, SOD3, TBX2
Most correlated modules
- Pericyte Identity · correlation 0.82
- Pericyte ECM Production · correlation 0.81
- Pericyte Identity Signaling · correlation 0.80
- Pericyte Inflammatory Activation · correlation 0.80
- Focal Adhesion Cytoskeleton · correlation 0.78
- BM Collagen Production · correlation 0.77
- Fibrotic ECM Remodeling · correlation 0.77
- Fibrotic ECM Remodeling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.