Pericyte Identity Signaling
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes are PDGFRB (the definitive pericyte receptor tyrosine kinase), NOTCH3 (canonical pericyte identity marker, mutations cause CADASIL), PLXDC1 (plexin domain containing, expressed in pericytes/vasculature), PEAK1 (pseudokinase scaffold, cytoskeletal/PDGFR signaling), ADCY3 (adenylyl cyclase, cAMP signaling), FBLIM1 (filamin-binding LIM protein, focal adhesion), CCDC102B, OLFML2B (olfactomedin-like, pericyte-enriched). PDGFRB+NOTCH3 are the two most canonical pericyte identity genes. This module captures core pericyte identity and PDGFR signaling, upregulated in intestinal inflammation.
Genes
ADCY3, CCDC102B, FBLIM1, NOTCH3, OLFML2B, PDGFRB, PEAK1, PLXDC1
Most correlated modules
- Pericyte Identity · correlation 0.91
- Pericyte ECM Production · correlation 0.90
- Pericyte Inflammatory Activation · correlation 0.86
- Hypoxia NO Signaling · correlation 0.86
- Fibrillar Collagen Production · correlation 0.82
- BM Collagen Production · correlation 0.82
- Pericyte Vascular Tone · correlation 0.80
- Pericyte Identity Differentiation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.